Optimization of esterification and transesterification of esters based on experiment planning

The operation of the optimization algorithm based on planning the experiment via a preliminary analysis of the number of the degrees of freedom has been demonstrated in the preparation of esters. An analysis of the number of degrees of freedom of both individual apparatuses (reactors, reactive distillation columns, and others) and process flow diagrams formed from them has been performed. Mathematical models of processes have been plotted by experiment planning and their optimization has been performed. It has been shown that, when using the principle of combination, substantial gains in energy consumption are achieved for the processes considered. Based on the studies performed, it has been suggested that combined process provides the gain in energy consumption compared to recirculation flowsheet in all cases where the preliminary removal of products from the reaction zone is maintained due to the separating component.