Temperature and concentration dependences of density and refraction of aqueous duloxetine solutions

Present paper reports the measured densities (ρ) and refractive indices ( n D ) of aqueous solutions of Duloxetine drug in wide range of molal concentrations ( m = 0.0101–0.1031 mol kg −1 ) and at different temperatures (297.15, 302.15, and 307.15 K). Apparent molar volumes (φ v ) of drug were calculated from density data and fitted to Masson’s relation and partial molar volumes (φ v 0 ) were evaluated at different temperatures. Concentration dependence of refractive index ( n D = Kc + n D 0 ) at experimental temperature has been studied. Density and refractive index data has been used for the calculation of specific refractions ( R D ). Experimental (ρ and n D ) and calculated (φ v , φ v 0 , and R D ) properties have been interpreted in terms of concentration and temperature effects on structural fittings and drug-water interactions.