Electron-conformational transformations in nanoscopic RyR channels governing both the heart’s contraction and beating

Electron-conformational transformations in nanoscopic RyR channels governing both the heart’s contraction and beating

We show that a simple biophysically based electron-conformational model of RyR channel can explain and describe on equal footing the oscillatory regime of the heart’s cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under C...

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Veröffentlicht in:JETP letters 2011-06, Vol.93 (7), p.403-408
Hauptverfasser: Moskvin, A. S., Ryvkin, A. M., Solovyova, O. E., Markhasin, V. S.
Format: Artikel
Sprache:eng
Schlagworte:
Atomic
Biological and Medical Physics
Biophysics
Molecular
Optical and Plasma Physics
Particle and Nuclear Physics
Physics
Physics and Astronomy
Quantum Information Technology
Solid State Physics
Spintronics
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Beschreibung
Zusammenfassung:We show that a simple biophysically based electron-conformational model of RyR channel can explain and describe on equal footing the oscillatory regime of the heart’s cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca 2+ sarcoplasmic reticulum overload.
ISSN:0021-3640
1090-6487
DOI:10.1134/S0021364011070083