A follow-up study: 6-year cART-free virologic control of rhesus macaques after PD-1-based DNA vaccination against pathogenic SHIV SF162P3CN challenge

Efficient strategies for HIV-1 cART-free virologic control are critical for ending the AIDS pandemic. The essential role of effector-memory CD8 T cells in controlling viremia and eliminating virus-infected cells has made them a promising target for vaccine development. It has been previously reporte...

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Veröffentlicht in:Microbiology spectrum 2023-12, Vol.11 (6), p.e0335023
Hauptverfasser: He, Xiaoen, Wong, Yik Chun, Zhong, Menglong, Mo, Yufei, Li, Bo, Yim, Lok Yan, Li, Xin, Liu, Wan, Du, Yanhua, Wang, Hui, Zhang, Haoji, Chen, Zhiwei
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Sprache:eng
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Zusammenfassung:Efficient strategies for HIV-1 cART-free virologic control are critical for ending the AIDS pandemic. The essential role of effector-memory CD8 T cells in controlling viremia and eliminating virus-infected cells has made them a promising target for vaccine development. It has been previously reported that PD-1-based DNA vaccination was effective in inducing polyfunctional effector-memory CD8 T cells for AIDS virus control for 2 years in rhesus monkeys. This follow-up study extends the findings and shows that a viremia-free period of over 6 years was detected in two monkeys immunized with PD-1-based DNA vaccine against pathogenic SHIV infection in the absence of antiretroviral therapy. Long-term vaccine-induced memory T cell responses were detected. Our results warrant the clinical trials of PD-1-based DNA vaccines for achieving HIV-1 cART-free virologic control used either alone or in combination with other biomedical interventions.
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.03350-23