Overexpression of genes involved in fatty acid biosynthesis increases lipid content in the NaHCO 3 -tolerant Chlorella sp. JB6

Overexpression of genes involved in fatty acid biosynthesis increases lipid content in the NaHCO 3 -tolerant Chlorella sp. JB6

Fatty acid (FA) contents can be altered in Chlorella JB6 in the presence of sodium bicarbonate (NaHCO ). Overexpression of the FA synthesis genes inhibited the growth of JB6 cells and decreased their resistance to NaHCO , but these transgenic JB6 strains could grow in a medium containing as high as...

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Veröffentlicht in:Microbiology spectrum 2024-01, Vol.12 (1), p.e0318423
Hauptverfasser: Shang, Hongna, Liu, Songsong, Xu, Chenghui, Liu, Shenkui, Liu, Hua
Format: Artikel
Sprache:eng
Schlagworte:
Biomass
Chlorella - genetics
Chlorella - metabolism
Fatty Acids - metabolism
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Zusammenfassung:Fatty acid (FA) contents can be altered in Chlorella JB6 in the presence of sodium bicarbonate (NaHCO ). Overexpression of the FA synthesis genes inhibited the growth of JB6 cells and decreased their resistance to NaHCO , but these transgenic JB6 strains could grow in a medium containing as high as 300 mM NaHCO . In JB6, ectopic expression of the FA synthesis genes increased the synthesis of very long-chain saturated FA (> 20C).
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.03184-23