Antimicrobial Treatment and Containment Measures for an Extremely Drug-Resistant Klebsiella pneumoniae ST101 Isolate Carrying pKPN101-IT, a Novel Fully Sequenced bla KPC-2 Plasmid

Antimicrobial Treatment and Containment Measures for an Extremely Drug-Resistant Klebsiella pneumoniae ST101 Isolate Carrying pKPN101-IT, a Novel Fully Sequenced bla KPC-2 Plasmid

An extremely drug-resistant Klebsiella pneumoniae isolate, sequence type ST101, was isolated from a patient in Italy. We describe antibiotic treatment, measures to clear and contain the infection, and a complete sequence analysis of a novel large plasmid, pKPN101-IT, harboring the bla KPC-2 gene and...

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Veröffentlicht in:Journal of clinical microbiology 2012-11, Vol.50 (11), p.3768-3772
Hauptverfasser: Frasson, Ilaria, Lavezzo, Enrico, Franchin, Elisa, Toppo, Stefano, Barzon, Luisa, Cavallaro, Antonietta, Richter, Sara N., Palù, Giorgio
Format: Artikel
Sprache:eng
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Zusammenfassung:An extremely drug-resistant Klebsiella pneumoniae isolate, sequence type ST101, was isolated from a patient in Italy. We describe antibiotic treatment, measures to clear and contain the infection, and a complete sequence analysis of a novel large plasmid, pKPN101-IT, harboring the bla KPC-2 gene and arising from the threatening recombination of different worldwide-distributed backbones.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01892-12