False-Positive IgM Serology in Coccidioidomycosis

False-Positive IgM Serology in Coccidioidomycosis

The clinical observation has been made that there might be an unacceptable number of false-positive enzyme immunoassay (EIA) test results for IgM among persons suspected of having coccidioidomycosis. Patients with a positive result for IgM by EIA are thought to have a diagnosis of acute coccidioidom...

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Veröffentlicht in:Journal of Clinical Microbiology 2010-06, Vol.48 (6), p.2047-2049
Hauptverfasser: Kuberski, Tim, Herrig, Judith, Pappagianis, D
Format: Artikel
Sprache:eng
Schlagworte:
Antibodies, Fungal - blood
Biological and medical sciences
Coccidioides - immunology
Coccidioidomycosis
Coccidioidomycosis - diagnosis
False Positive Reactions
Fundamental and applied biological sciences. Psychology
Human mycoses
Humans
Immunoenzyme Techniques - methods
Immunoglobulin G - blood
Immunoglobulin M - blood
Infectious diseases
Male
Medical sciences
Microbiology
Mycology
Mycoses
Serology - methods
Tropical mycoses
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Beschreibung
Zusammenfassung:The clinical observation has been made that there might be an unacceptable number of false-positive enzyme immunoassay (EIA) test results for IgM among persons suspected of having coccidioidomycosis. Patients with a positive result for IgM by EIA are thought to have a diagnosis of acute coccidioidomycosis. However, this study found that 82% of patients with an IgM-positive and IgG-negative EIA result did not have coccidioidomycosis.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01843-09