Hypervirulence of a Rough Variant of the Mycobacterium abscessus Type Strain

We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by...

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Veröffentlicht in:	Infection and Immunity 2007-02, Vol.75 (2), p.1055-1058
Hauptverfasser:	Catherinot, E, Clarissou, J, Etienne, G, Ripoll, F, Emile, J.-F, Daffé, M, Perronne, C, Soudais, C, Gaillard, J.-L, Rottman, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Infections Biological and medical sciences Disease Models, Animal Fundamental and applied biological sciences. Psychology Glycolipids - biosynthesis Glycopeptides - biosynthesis Macrophages - immunology Mice Mice, Inbred C57BL Microbiology Mutation Mycobacterium abscessus Mycobacterium chelonae - immunology Mycobacterium chelonae - pathogenicity Mycobacterium chelonae - physiology Mycobacterium Infections, Nontuberculous - immunology Mycobacterium Infections, Nontuberculous - microbiology Survival Analysis Tumor Necrosis Factor-alpha - biosynthesis Virulence
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Zusammenfassung:	We isolated a rough variant of Mycobacterium abscessus CIP 104536T during experimental infection of mice. We show that this variant has lost the ability to produce glycopeptidolipids, is hyperlethal for C57BL/6 mice infected intravenously, and induces a strong tumor necrosis factor-alpha response by murine monocyte-derived macrophages.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.00835-06