First Report of the Carbapenemase Gene bla OXA-499 in Acinetobacter pittii

We identified the carbapenemase gene , a variant of , from a clinical isolate of for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible sp...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2017-05, Vol.61 (5)
Hauptverfasser:	D'Souza, Roshan, Pinto, Naina Adren, Higgins, Paul G, Hwang, Insik, Yong, Dongeun, Choi, Jongrak, Lee, Kyoungwon, Chong, Yunsop
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter - drug effects Acinetobacter - genetics Acinetobacter - isolation & purification Acinetobacter Infections - drug therapy Acinetobacter Infections - microbiology Aged Anti-Bacterial Agents - pharmacology Bacterial Proteins - genetics beta-Lactam Resistance - genetics beta-Lactamases - genetics Carbapenems - pharmacology DNA, Bacterial - genetics Humans Male Microbial Sensitivity Tests Sequence Analysis, DNA
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Zusammenfassung:	We identified the carbapenemase gene , a variant of , from a clinical isolate of for the first time. OXA-499 shared 93.1% amino acid identity with OXA-143, and the gene was located on the chromosome. By cloning the OXA-499-encoding gene into the pWH1266 vector and transforming it into susceptible spp., we were able to show that OXA-499 confers resistance to carbapenems.
ISSN:	0066-4804 1098-6596
DOI:	10.1128/AAC.02676-16