Paper of note in Science Immunology

Abstract only This week’s article shows that by inducing expression of the gene encoding the transcription factor Blimp-1, the cytokine IL-10 restrains autoimmune responses. CYTOKINES Regulating Blimp-1 in T H 2 cells STAT3-mediated Blimp-1 induction in T cells antagonizes STAT5’s role in promoting cell cycle and cell survival genes. A. C. Poholek, D. Jankovic, A. V. Villarino, F. Petermann, A. Hettinga, D. S. Shouval, S. B. Snapper, S. M. Kaech, S. R. Brooks, G. Vahedi, A. Sher, Y. Kanno, J. J. O’Shea, IL-10 induces a STAT3-dependent autoregulatory loop in T H 2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci . Immunol . 1 , eaaf8612 (2016). [Abstract]