Toxicity of Mild Prenatal Carbon Monoxide Exposure

Rats prenatally exposed to a low concentration of carbon monoxide which results in carboxyhemoglobin levels equivalent to those maintained by human cigarette smokers, show reduced birth weight and decreased weight gain. Neurobehavioral and biochemical testing of the offspring reveals lower behaviora...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1977-08, Vol.197 (4304), p.680-682
Hauptverfasser:	Fechter, Laurence D., Annau, Zoltan
Format:	Artikel
Sprache:	eng
Schlagworte:	560304 > Chemicals Metabolism & Toxicology-- Invertebrates-- (-1987) ANIMALS Animals, Newborn - physiology BEHAVIOR Behavior, Animal - drug effects BIOLOGICAL EFFECTS Birth weight Birth Weight - drug effects BODY Body Weight - drug effects BRAIN Brain - metabolism CARBON COMPOUNDS CARBON MONOXIDE Carbon Monoxide - toxicity CARBON OXIDES CARBOXYHEMOGLOBIN Catecholamines CENTRAL NERVOUS SYSTEM CHALCOGENIDES Cigarette smoking Cigarettes Control groups Disease Models, Animal Dopamine - metabolism Female Fetus - drug effects Levodopa - pharmacology MAMMALS Maternal-Fetal Exchange METABOLISM MORPHOLOGICAL CHANGES Motor Activity - drug effects Nerve Tissue Proteins - metabolism NERVOUS SYSTEM Newborns Norepinephrine Norepinephrine - metabolism ORGANIC COMPOUNDS ORGANS OXIDES OXYGEN COMPOUNDS Pregnancy PROGENY PROTEINS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RODENTS Smoking - complications TOXICITY ULTRASTRUCTURAL CHANGES VERTEBRATES 560300 > Chemicals Metabolism & Toxicology
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Zusammenfassung:	Rats prenatally exposed to a low concentration of carbon monoxide which results in carboxyhemoglobin levels equivalent to those maintained by human cigarette smokers, show reduced birth weight and decreased weight gain. Neurobehavioral and biochemical testing of the offspring reveals lower behavioral activity levels through the preweaning period, altered central catecholamine activity, and reduction in total brain protein at birth.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.877585