Photoreceptor mutant of Drosophila : is protein involved in intermediate steps of phototransduction?

In norpA mutants of Drosophila melanogaster the phototransduction process is either partially or completely blocked. By using a temperature-sensitive allele, we have found that the norpA mutation has little or no effect on either the rhodopsin-metarhodopsin transition or the machinery of quantum bum...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1976-01, Vol.194 (4268), p.956-959
Hauptverfasser: Pak, W.L, Ostroy, S.E, Deland, M.C, Wu, C.F
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Sprache:eng
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Zusammenfassung:In norpA mutants of Drosophila melanogaster the phototransduction process is either partially or completely blocked. By using a temperature-sensitive allele, we have found that the norpA mutation has little or no effect on either the rhodopsin-metarhodopsin transition or the machinery of quantum bump production. Thus, the norpA lesion appears to be localized in the intermediate process of phototransduction. Because a temperature-sensitive allele of norpA has been isolated, the norpA gene probably encodes a protein involved in the process.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.824732