Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats
Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1981-02, Vol.211 (4485), p.957-959 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 959 |
|---|---|
| container_issue | 4485 |
| container_start_page | 957 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 211 |
| creator | West, J.R. Hodges, C.A. Black, A.C. |
| description | Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome. |
| doi_str_mv | 10.1126/science.7466371 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1126_science_7466371</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>80000286</jstor_id><sourcerecordid>80000286</sourcerecordid><originalsourceid>FETCH-LOGICAL-c410t-1a532249f0a2167368bcc2bebe438ce5fdefb5dd7fd4c88ed4dff64047f813c23</originalsourceid><addsrcrecordid>eNplkE1Lw0AURQdRaq2uXQnzB9LOVyaTZSmtFSoVUXAXJvNhU5JMmJmC9deb0tCNq7c49z7eOwA8YjTFmPBZUJVplZlmjHOa4SswxihPk5wgeg3GCFGeCJSlt-AuhD1CPcvpCIyG-Bh8vXnTyihruPzpXDh4A6ODy7iTravhvI7GBxh3Bm79t2yrXxkr10Jn4brqOqdk0_XVVxfCEa6q8hSuWvguY7gHN1bWwTwMcwI-V8uPxTrZbJ9fFvNNohhGMcEypYSw3CJJMM8oF6VSpDSlYVQok1ptbJlqnVnNlBBGM20tZ4hlVmCqCJ2A2Xmv8v0V3tii81Uj_bHAqDgpKgZFxfBz33g6N7pD2Rh9yf_j-xCdv2DR20NEcPoHSmtugA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>West, J.R. ; Hodges, C.A. ; Black, A.C.</creator><creatorcontrib>West, J.R. ; Hodges, C.A. ; Black, A.C.</creatorcontrib><description>Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7466371</identifier><identifier>PMID: 7466371</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Abnormalities, Drug-Induced - etiology ; Animals ; Brain ; Dams ; Dentate gyrus ; Diet ; Ethanol ; Ethanol - pharmacology ; Female ; Hippocampus ; Hippocampus - abnormalities ; Hippocampus - drug effects ; Hippocampus - embryology ; Intellectual disability ; Nutrient utilization ; Pregnancy ; Pregnancy, Animal - drug effects ; Pyramidal cells ; Rats</subject><ispartof>Science (American Association for the Advancement of Science), 1981-02, Vol.211 (4485), p.957-959</ispartof><rights>Copyright 1981 The American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-1a532249f0a2167368bcc2bebe438ce5fdefb5dd7fd4c88ed4dff64047f813c23</citedby><cites>FETCH-LOGICAL-c410t-1a532249f0a2167368bcc2bebe438ce5fdefb5dd7fd4c88ed4dff64047f813c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/80000286$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/80000286$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7466371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>West, J.R.</creatorcontrib><creatorcontrib>Hodges, C.A.</creatorcontrib><creatorcontrib>Black, A.C.</creatorcontrib><title>Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome.</description><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Animals</subject><subject>Brain</subject><subject>Dams</subject><subject>Dentate gyrus</subject><subject>Diet</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Hippocampus</subject><subject>Hippocampus - abnormalities</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - embryology</subject><subject>Intellectual disability</subject><subject>Nutrient utilization</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - drug effects</subject><subject>Pyramidal cells</subject><subject>Rats</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkE1Lw0AURQdRaq2uXQnzB9LOVyaTZSmtFSoVUXAXJvNhU5JMmJmC9deb0tCNq7c49z7eOwA8YjTFmPBZUJVplZlmjHOa4SswxihPk5wgeg3GCFGeCJSlt-AuhD1CPcvpCIyG-Bh8vXnTyihruPzpXDh4A6ODy7iTravhvI7GBxh3Bm79t2yrXxkr10Jn4brqOqdk0_XVVxfCEa6q8hSuWvguY7gHN1bWwTwMcwI-V8uPxTrZbJ9fFvNNohhGMcEypYSw3CJJMM8oF6VSpDSlYVQok1ptbJlqnVnNlBBGM20tZ4hlVmCqCJ2A2Xmv8v0V3tii81Uj_bHAqDgpKgZFxfBz33g6N7pD2Rh9yf_j-xCdv2DR20NEcPoHSmtugA</recordid><startdate>19810227</startdate><enddate>19810227</enddate><creator>West, J.R.</creator><creator>Hodges, C.A.</creator><creator>Black, A.C.</creator><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19810227</creationdate><title>Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats</title><author>West, J.R. ; Hodges, C.A. ; Black, A.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-1a532249f0a2167368bcc2bebe438ce5fdefb5dd7fd4c88ed4dff64047f813c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Abnormalities, Drug-Induced - etiology</topic><topic>Animals</topic><topic>Brain</topic><topic>Dams</topic><topic>Dentate gyrus</topic><topic>Diet</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Hippocampus</topic><topic>Hippocampus - abnormalities</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - embryology</topic><topic>Intellectual disability</topic><topic>Nutrient utilization</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - drug effects</topic><topic>Pyramidal cells</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>West, J.R.</creatorcontrib><creatorcontrib>Hodges, C.A.</creatorcontrib><creatorcontrib>Black, A.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>West, J.R.</au><au>Hodges, C.A.</au><au>Black, A.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1981-02-27</date><risdate>1981</risdate><volume>211</volume><issue>4485</issue><spage>957</spage><epage>959</epage><pages>957-959</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>7466371</pmid><doi>10.1126/science.7466371</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1981-02, Vol.211 (4485), p.957-959 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_crossref_primary_10_1126_science_7466371 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Abnormalities, Drug-Induced - etiology Animals Brain Dams Dentate gyrus Diet Ethanol Ethanol - pharmacology Female Hippocampus Hippocampus - abnormalities Hippocampus - drug effects Hippocampus - embryology Intellectual disability Nutrient utilization Pregnancy Pregnancy, Animal - drug effects Pyramidal cells Rats |
| title | Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T13%3A38%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prenatal%20Exposure%20to%20Ethanol%20Alters%20the%20Organization%20of%20Hippocampal%20Mossy%20Fibers%20in%20Rats&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=West,%20J.R.&rft.date=1981-02-27&rft.volume=211&rft.issue=4485&rft.spage=957&rft.epage=959&rft.pages=957-959&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.7466371&rft_dat=%3Cjstor_cross%3E80000286%3C/jstor_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/7466371&rft_jstor_id=80000286&rfr_iscdi=true |