Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats

Prenatal Exposure to Ethanol Alters the Organization of Hippocampal Mossy Fibers in Rats

Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1981-02, Vol.211 (4485), p.957-959
Hauptverfasser: West, J.R., Hodges, C.A., Black, A.C.
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities, Drug-Induced - etiology
Animals
Brain
Dams
Dentate gyrus
Diet
Ethanol
Ethanol - pharmacology
Female
Hippocampus
Hippocampus - abnormalities
Hippocampus - drug effects
Hippocampus - embryology
Intellectual disability
Nutrient utilization
Pregnancy
Pregnancy, Animal - drug effects
Pyramidal cells
Rats
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Zusammenfassung:Rats exposed to ethanol throughout their gestation were found to have abnormally distributed mossy fibers in temporal regions of the hippocampus. This demonstrates that prenatal exposure to ethanol causes alterations in neuronal circuitry that persist to maturity. Such defects may play a role in the mental retardation often observed in children with fetal alcohol syndrome.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7466371