Anesthetics as Teratogens: Nitrous Oxide Is Fetotoxic, Xenon Is not

Anesthetics as Teratogens: Nitrous Oxide Is Fetotoxic, Xenon Is not

Exposure of pregnant rats to the anesthetic nitrous oxide on the ninth day of gestation causes fetal resorption, skeletal anomalies, and macroscopic lesions including encephalocele, anophthalmia, microphthalmia, and gastroschisis. The inert gas xenon, which has anesthetic properties similar to those...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1980-11, Vol.210 (4472), p.899-901
Hauptverfasser: Lane, Geoffrey A., Nahrwold, Michael L., Tait, Alan R., Taylor-Busch, Margaret, Cohen, Peter J., Beaudoin, Allan R.
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Anesthesiology
Anesthetics
Anesthetics - adverse effects
Animals
Control groups
Encephalocele
Female
Fetus
Inhalation anesthetics
Nitrous oxide
Nitrous Oxide - toxicity
Pregnancy
Rats
Steels
Structure-Activity Relationship
Teratogens
Xenon
Xenon - toxicity
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Beschreibung
Zusammenfassung:Exposure of pregnant rats to the anesthetic nitrous oxide on the ninth day of gestation causes fetal resorption, skeletal anomalies, and macroscopic lesions including encephalocele, anophthalmia, microphthalmia, and gastroschisis. The inert gas xenon, which has anesthetic properties similar to those of nitrous oxide, does not cause teratogenic effects under the same experimental conditions.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7434002