Prenatal Exposure to Carbon Monoxide: Learning and Memory Deficits

Exposing pregnant rats to carbon monoxide (150 parts per million) produced only minor reductions in the birth weights of the pups and gave no evidence of overt teratogenesis. However, behavioral evaluation of learning and memory processes in a two-way avoidance task suggested a functional deficit in...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1984-01, Vol.223 (4634), p.409-411
Hauptverfasser:	Mactutus, Charles F., Fechter, Laurence D.
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) Animal ANIMALS Avoidance Learning - drug effects BEHAVIOR Biological and medical sciences Birth weight Birth Weight - drug effects CARBON COMPOUNDS CARBON MONOXIDE Carbon Monoxide - toxicity CARBON OXIDES CENTRAL NERVOUS SYSTEM CHALCOGENIDES CHRONIC EXPOSURE Conditioning Conditioning (Psychology) Control groups Covariance Dams Female FETUSES Fundamental and applied biological sciences. Psychology INJURIES Learning Learning. Memory Male MAMMALS Memory Memory - drug effects Memory disorders NERVOUS SYSTEM OXIDES OXYGEN COMPOUNDS PREGNANCY PRENATAL EXPOSURE Prenatal Exposure Delayed Effects Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pups RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS RODENTS SENSITIVITY TERATOGENESIS TOXICITY VERTEBRATES
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Zusammenfassung:	Exposing pregnant rats to carbon monoxide (150 parts per million) produced only minor reductions in the birth weights of the pups and gave no evidence of overt teratogenesis. However, behavioral evaluation of learning and memory processes in a two-way avoidance task suggested a functional deficit in the central nervous system of the exposed offspring. Multiple dependent measures and specific control groups confirmed that this deficit was independent of nonassociative or motivational alterations.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.6691152