Radiation from Tritiated Thymidine Perturbs the Cell Cycle Progression of Stimulated Lymphocytes

Tritiated thymidine was found to affect the cell cycle progression of phytohemagglutinin-stimulated human lymphocytes. By means of flow cytometry a statistically significant increase in the G$_{2}$ and M phases of the cell cycle was observed in cultures with low concentrations of tritiated thymidine...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1979-03, Vol.203 (4384), p.1025-1027
Hauptverfasser:	Pollack, Alan, Bagwell, C. Bruce, Irvin, George L.
Format:	Artikel
Sprache:	eng
Schlagworte:	560122 - Radiation Effects on Cells- Internal Source- (-1987) 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man AGGLUTININS ANIMAL CELLS AZINES BIOLOGICAL EFFECTS BIOLOGICAL MATERIALS BIOLOGICAL RADIATION EFFECTS BLOOD BLOOD CELLS BODY FLUIDS CARBOHYDRATES CELL CULTURES CELL CYCLE Cell Cycle - drug effects Cell Cycle - radiation effects CELL FLOW SYSTEMS Cell lines Cells CHROMOSOMAL ABERRATIONS CONNECTIVE TISSUE CELLS Cultured cells Dose-Response Relationship, Radiation DOSE-RESPONSE RELATIONSHIPS Dyes HEMAGGLUTININS HETEROCYCLIC COMPOUNDS Histograms Humans LABELLED COMPOUNDS LEUKOCYTES Lymphocyte Activation - radiation effects LYMPHOCYTES Lymphocytes - radiation effects MATERIALS Memory interference MITOGENS Mitosis Mitosis - radiation effects MUCOPROTEINS MUTATIONS NUCLEOSIDES NUCLEOTIDES ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PHYTOHEMAGGLUTININ Phytohemagglutinins - pharmacology POLYSACCHARIDES PROTEINS PYRIMIDINES RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RIBOSIDES SACCHARIDES SIDE EFFECTS SOMATIC CELLS THYMIDINE Thymidine - pharmacology Time Factors Tritium TRITIUM COMPOUNDS
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Zusammenfassung:	Tritiated thymidine was found to affect the cell cycle progression of phytohemagglutinin-stimulated human lymphocytes. By means of flow cytometry a statistically significant increase in the G$_{2}$ and M phases of the cell cycle was observed in cultures with low concentrations of tritiated thymidine added 18 hours before the cultures were harvested.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.424727