Acute Lymphoblastic Leukemic Cells with T (Thymus-Derived) Lymphocyte Markers

Five of nine children with acute lymphoblastic leukemia had lymphoblasts that bound sheep erythrocytes or reacted with antiserum to thymocytes, suggesting involvement of T (thymus-derived) cells. When lymphoblasts from all patients were examined by immunofluorescence they were found to lack a marker...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1973-12, Vol.182 (4119), p.1355-1356
Hauptverfasser:	Kersey, John H., Sabad, Andrej, Gajl-Peczalska, Kazimiera, Hallgren, Helen M., Yunis, Edmond J., Nesbit, Mark E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Antiserum B lymphocytes B-Lymphocytes - immunology Blood Child Child, Preschool Complement System Proteins Cytotoxicity Cytotoxicity Tests, Immunologic Erythrocytes Erythrocytes - immunology Female Fluorescent Antibody Technique Goats - immunology Humans Immune Adherence Reaction Infant Leukemia Leukemia, Lymphoid - immunology Lymphocytes Male Phagocytes Sheep - immunology T lymphocytes T-Lymphocytes - immunology Thymocytes
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Beschreibung
Zusammenfassung:	Five of nine children with acute lymphoblastic leukemia had lymphoblasts that bound sheep erythrocytes or reacted with antiserum to thymocytes, suggesting involvement of T (thymus-derived) cells. When lymphoblasts from all patients were examined by immunofluorescence they were found to lack a marker for B (bone marrow or bursa-equivalent) cells, that is, the presence of surface immunoglobulins.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.182.4119.1355