Type C Virus from Cell Cultures of Chemically Induced Rat Hepatomas

Type C Virus from Cell Cultures of Chemically Induced Rat Hepatomas

Type C RNA viruses are present in cell cultures from transplantable and primary hepatomas induced by aromatic amine carcinogens. Virus yield was markedly enhanced by treating the cells with bromodeoxyuridine. Preparations of rat hepatoma-associated virus obtained from cultures treated with this comp...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1972-12, Vol.178 (4065), p.1098-1100
Hauptverfasser: Weinstein, I. Bernard, Gebert, Ronald, Stadler, Ulrike C., Orenstein, Jan M., Axel, Richard
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Avian Leukosis Virus - metabolism
Bromodeoxyuridine - pharmacology
Carcinogens
Carcinoma, Hepatocellular - chemically induced
Carcinoma, Hepatocellular - microbiology
Cell culture techniques
Cell lines
Cells, Cultured
Ceramides
Deoxyribonucleotides - metabolism
Dimethyl Sulfoxide - pharmacology
DNA
DNA Nucleotidyltransferases - metabolism
Epithelial cells
Farber lipogranulomatosis
Fluorenes
Hepatocellular carcinoma
Liver Neoplasms - chemically induced
Liver Neoplasms - microbiology
Microscopy, Electron
Neoplasms, Experimental - microbiology
Oncogenic Viruses - growth & development
Rats
Retroviridae - drug effects
Retroviridae - enzymology
Retroviridae - growth & development
Retroviridae - metabolism
RNA
RNA Viruses - growth & development
RNA, Viral - analysis
RNA, Viral - biosynthesis
Tritium
Uridine - metabolism
Viruses
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Zusammenfassung:Type C RNA viruses are present in cell cultures from transplantable and primary hepatomas induced by aromatic amine carcinogens. Virus yield was markedly enhanced by treating the cells with bromodeoxyuridine. Preparations of rat hepatoma-associated virus obtained from cultures treated with this compound were deficient in DNA polymerase activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.178.4065.1098