Induction of Benzo[α]pyrene Hydroxylase in Human Skin

Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxy...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1972-04, Vol.176 (4033), p.419-420
Hauptverfasser:	Levin, W., Conney, A. H., Alvares, A. P., Merkatz, I., Kappas, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Antiserum Benz(a)Anthracenes - pharmacology Benzopyrenes Carcinogens Cigarette smoking Culture Techniques Enzyme Induction Enzymes Foreskin Gels Humans Immunoglobulins Infant, Newborn Male Mixed Function Oxygenases - analysis Mixed Function Oxygenases - metabolism NADP - pharmacology Penis Skin - enzymology Tissue culture techniques Viruses
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Beschreibung
Zusammenfassung:	Foreskins from children who were circumcised 2 to 4 days after birth contain an enzyme system that hydroxylates the carcinogen benzo[α]pyrene. When foreskin was cultured for 16 hours in the presence of 10 micromolar benz[α]anthracene, a two- to fivefold increase in activity of benzo[α]pyrene hydroxylase was obtained. An evaluation of the basal activity and inducibility of carcinogen-metabolizing enzymes in human tissues may provide a means of determining the ability of different individuals to metabolize carcinogens.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.176.4033.419