Melatonin and Abnormal Movements Induced by L-Dopa in Mice

Melatonin has blocked adventitious movements induced by L-dopa in intact mice. It has reversed the adventitious turning to the right, and it has induced running to the left in mice receiving L-dopa after a lesion in the right caudate nucleus.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1971-07, Vol.173 (3995), p.450-452
Hauptverfasser:	Cotzias, G. C., Tang, L. C., Miller, S. T., Ginos, J. Z.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Apomorphine - administration & dosage Biochemistry Brain Chemistry Caudate Nucleus - physiopathology Caudate Nucleus - surgery Dihydroxyphenylalanine - administration & dosage Dihydroxyphenylalanine - toxicity Dopamine - isolation & purification Drug Antagonism Dyskinesia Injections, Intraperitoneal Intraperitoneal injections Lethal Dose 50 Male Melanocyte-Stimulating Hormones - administration & dosage Melanocyte-Stimulating Hormones - metabolism Melanocyte-Stimulating Hormones - toxicity Mice Movement Disorders - chemically induced Movement Disorders - etiology Neurotransmitters Parkinsonian disorders Serotonin - isolation & purification Time Factors
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Beschreibung
Zusammenfassung:	Melatonin has blocked adventitious movements induced by L-dopa in intact mice. It has reversed the adventitious turning to the right, and it has induced running to the left in mice receiving L-dopa after a lesion in the right caudate nucleus.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.173.3995.450