Harderian Gland: Influence on Pineal Hydroxyindole-O-Methyltransferase Activity in Neonatal Rats

Harderian Gland: Influence on Pineal Hydroxyindole-O-Methyltransferase Activity in Neonatal Rats

A circadian rhythm has been found in hydroxyindole-O-methyltransferase activity of the pineal gland of blinded 12-day-old rats. Five additional hours of lighting can partly prevent the nocturnal increase in pineal hydroxyindole-O-methyltransferase activity in such rats. Removal of the Harderian glan...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1970-10, Vol.170 (3954), p.194-196
Hauptverfasser: Wetterberg, Lennart, Yuwiler, Arthur, Ulrich, Renee, Geller, Edward, Wallace, Raymond
Format: Artikel
Sprache:eng
Schlagworte:
Animal glands
Animals
Animals, Newborn - physiology
Carbon Isotopes
Circadian rhythm
Darkness
Eyes
Immatures
Lacrimal Apparatus - physiology
Light
Melatonin - biosynthesis
Mothers
Pineal gland
Pineal Gland - enzymology
Porphyrins
Radiation Effects
Rats
Suckling
Transferases - metabolism
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Zusammenfassung:A circadian rhythm has been found in hydroxyindole-O-methyltransferase activity of the pineal gland of blinded 12-day-old rats. Five additional hours of lighting can partly prevent the nocturnal increase in pineal hydroxyindole-O-methyltransferase activity in such rats. Removal of the Harderian gland abolishes this response to light in 12-day-old blinded animals, giving further support to the suggestion that this gland may function as an extraretinal photosensitive organ influencing the pineal gland in blinded suckling rats.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.170.3954.194