Antitumor Activity in Mice of Tentacles of Two Tropical Sea Annelids

Antitumor Activity in Mice of Tentacles of Two Tropical Sea Annelids

Crude extracts of tentacles of two polychaetous annelids completely inhibit growth of Erlich ascites tumor in 60 to 100 percent of treated mice. Dialyzed extracts of one of these annelids, Lanice conchilega, show activity in the retentate after pronase digestion, suggesting that antitumor activity i...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1970-10, Vol.170 (3954), p.181-183
Hauptverfasser: Tabrah, Frank L., Kashiwagi, Midori, Norton, Ted R.
Format: Artikel
Sprache:eng
Schlagworte:
Ascites
Dialysis
Dosage
Ethanol
Mice
Refrigeration
Spleen
Survival rates
Tumors
Worms
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Zusammenfassung:Crude extracts of tentacles of two polychaetous annelids completely inhibit growth of Erlich ascites tumor in 60 to 100 percent of treated mice. Dialyzed extracts of one of these annelids, Lanice conchilega, show activity in the retentate after pronase digestion, suggesting that antitumor activity is associated with a nonprotein component of the crude tentacle extract.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.170.3954.181