Tumorigenesis in Mouse Skin: Inhibition by Synthetic Inhibitors of Proteases

Three synthetic inhibitors of proteases (tosyl lysine chloromethyl ketone, tosyl phenylalanine chloromethyl ketone, and tosyl arginine methyl ester) inhibit the tumorigenesis initiated in mouse skin by 7,12-dimethylbenz(a)anthracene and promoted by croton oil or its active principle, phorbol ester....

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1970-09, Vol.169 (3951), p.1211-1213
Hauptverfasser:	Troll, Walter, Klassen, Arnold, Janoff, Aaron
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Arginine Benz(a)Anthracenes - antagonists & inhibitors Carcinogens Cell Transformation, Neoplastic - drug effects Chymotrypsin - antagonists & inhibitors Croton Oil - antagonists & inhibitors Depression, Chemical Enzymes Erythema Esters - pharmacology Ketones Ketones - pharmacology Lysine Lysosomes Mice Papain - antagonists & inhibitors Phenylalanine Phorbol esters Protease inhibitors Skin Neoplasms - chemically induced Terpenes - antagonists & inhibitors Trypsin Inhibitors - pharmacology Tumors
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Beschreibung
Zusammenfassung:	Three synthetic inhibitors of proteases (tosyl lysine chloromethyl ketone, tosyl phenylalanine chloromethyl ketone, and tosyl arginine methyl ester) inhibit the tumorigenesis initiated in mouse skin by 7,12-dimethylbenz(a)anthracene and promoted by croton oil or its active principle, phorbol ester. These protease inhibitors, when applied directly to mouse skin, inhibit some of the irritant effects of the tumor promoter and are not toxic.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.169.3951.1211