Demyelinating Encephalomyelopathy Associated with Lead Poisoning in Nonhuman Primates

Lead poisoning was diagnosed in four primates by the finding of toxic amounts of lead in tissues. Abnormalities in the brain and spinal cord were characterized by vascular lesions and demyelination. These findings suggest a new animal model for the study of demyelination and strengthen the suppositi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1970-09, Vol.169 (3950), p.1091-1093
Hauptverfasser:	Sauer, R. M., Zook, B. C., Garner, F. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ANIMALS BIOLOGICAL ACCUMULATION Blindness - veterinary BODY BRAIN Brain - pathology CENTRAL NERVOUS SYSTEM Cerebral Cortex - pathology Convulsions Demyelinating diseases Demyelinating Diseases - etiology Demyelinating Diseases - veterinary Disease Models, Animal DISTRIBUTION ELEMENTS Epilepsy Epilepsy - veterinary Female Hominidae LEAD Lead poisoning Lead Poisoning - complications Lead Poisoning - veterinary Lesions Liver Male MAMMALS MATHEMATICAL MODELS METALS Monkey Diseases - pathology MONKEYS NERVOUS SYSTEM ORGANS PATHOLOGICAL CHANGES PRIMATES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT SPINAL CORD TISSUE DISTRIBUTION TOXICITY VERTEBRATES
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Beschreibung
Zusammenfassung:	Lead poisoning was diagnosed in four primates by the finding of toxic amounts of lead in tissues. Abnormalities in the brain and spinal cord were characterized by vascular lesions and demyelination. These findings suggest a new animal model for the study of demyelination and strengthen the supposition that lead may be a factor in some idiopathic demyelinating diseases.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.169.3950.1091