Cell-Mediated Immunity to Antigens Associated with Endogenous Murine C-Type Leukemia Viruses

Cell-Mediated Immunity to Antigens Associated with Endogenous Murine C-Type Leukemia Viruses

Splenic lymphocytes from (BALB/c × A/J) F$_{1}$ mice are cytotoxic for BALB/c fibroblasts infected with an endogenous C-type leukemia virus, but are not cytotoxic for uninfected BALB/c fibroblasts. These results indicate that mice do not exhibit cell-mediated immune tolerance to antigens associated...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1975-03, Vol.187 (4180), p.959-961
Hauptverfasser: Hirsch, Martin E., Kelly, Ann P., Proffitt, Max R., Black, Paul H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigens
Antigens, Viral
Cell Line
Cell lines
Cytotoxicity Tests, Immunologic
Embryonic cells
Fibroblasts
Genotype
Hamsters
Histocompatibility
Immunity, Cellular
Leukemia
Leukemia Virus, Murine - immunology
Lymphocytes
Lymphocytes - immunology
Male
Mating behavior
Mice
Mice, Inbred A
Mice, Inbred BALB C
Retroviridae - immunology
Species Specificity
Spleen - cytology
Spleen - immunology
Viruses
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Zusammenfassung:Splenic lymphocytes from (BALB/c × A/J) F$_{1}$ mice are cytotoxic for BALB/c fibroblasts infected with an endogenous C-type leukemia virus, but are not cytotoxic for uninfected BALB/c fibroblasts. These results indicate that mice do not exhibit cell-mediated immune tolerance to antigens associated with endogenous C-type viruses.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.167435