Mouse Leukemia Virus Activation by Chemical Carcinogens

The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1969-12, Vol.166 (3913), p.1624-1626
Hauptverfasser:	Igel, Howard J., Huebner, Robert J., Turner, Horace C., Kotin, Paul, Falk, Hans L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody Formation Antigens Carcinogens Complement Fixation Tests Leukemia Leukemia Virus, Murine - immunology Lymphoma Lymphoma - chemically induced Lymphoma - immunology Male animals Methylcholanthrene Mice Molecules Murine leukemia virus Nitrosamines Salts Urethane Viruses
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Beschreibung
Zusammenfassung:	The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leukemia virus is an indigenous actuating cause of the lymphomas.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.166.3913.1624