Toxin from Skin of Frogs of the Genus Atelopus: Differentiation from Dendrobatid Toxins

Toxin from Skin of Frogs of the Genus Atelopus: Differentiation from Dendrobatid Toxins

A potent, dialyzable toxin (atelopidtoxin) occurs in the skin of frogs of the genus Atelopus. A concentrate of atelopidtoxin from Atelopus zeteki has an LD$_{50}$ in mice of 16 micrograms per kilogram. It differs from batrachotoxin, tetrodotoxin, and saxitoxin, the only known nonprotein substances o...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1969-09, Vol.165 (3900), p.1376-1377
Hauptverfasser: Fuhrman, Frederick A., Fuhrman, Geraldine J., Mosher, Harry S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anura
Dialysis
Dosage
Eyes
Frogs
Lethal dose
Mice
Pharmacology
Saxitoxin
Skin - analysis
Tissue Extracts - toxicity
Toxicity
Toxins
Toxins, Biological - isolation & purification
Toxins, Biological - pharmacology
Visual stimulation
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Beschreibung
Zusammenfassung:A potent, dialyzable toxin (atelopidtoxin) occurs in the skin of frogs of the genus Atelopus. A concentrate of atelopidtoxin from Atelopus zeteki has an LD$_{50}$ in mice of 16 micrograms per kilogram. It differs from batrachotoxin, tetrodotoxin, and saxitoxin, the only known nonprotein substances of greater toxicity, as well as from all toxins previously isolated from amphibia.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.165.3900.1376