Cholinesterase in Plasma: First Reported Absence in the Bantu; Half-life Determination

A Bantu schoolgirl is the first non-Caucasoid found homozygous for the "silent" cholinesterase gene. Investigation of her family revealed two heterozygotes. The propositus possesses no antibody to normal cholinesterase. Transfused cholinesterase had in her a half-life of approximately 10 d...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1967-06, Vol.156 (3783), p.1748-1750
Hauptverfasser:	Jenkins, Trefor, Balinsky, Doris, Patient, D. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent African Continental Ancestry Group Alleles Blood Blood plasma Blood transfusion Cholinesterases - blood Dibucaine Enzymes Female Fluorides Genes, Regulator Half lives Heterozygote Heterozygotes Homozygote Humans Medical genetics Metabolism, Inborn Errors Succinylcholine
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Zusammenfassung:	A Bantu schoolgirl is the first non-Caucasoid found homozygous for the "silent" cholinesterase gene. Investigation of her family revealed two heterozygotes. The propositus possesses no antibody to normal cholinesterase. Transfused cholinesterase had in her a half-life of approximately 10 days.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.156.3783.1748