Cycasin: Radiomimetic Effect

Cycasin, methylazoxy-methanol-β-glucoside, a carcinogenic compound that occurs naturally in cycad plants, induces chromosome aberrations in the root-tip cells of Allium cepa. Germination and growth in an aqueous solution of cycasin at a concentration of only 3 percent of that found in Cycas circinal...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1965-07, Vol.149 (3683), p.541-542
Hauptverfasser:	Teas, Howard J., Sax, Hally J., Sax, Karl
Format:	Artikel
Sprache:	eng
Schlagworte:	Albinism ALLIUM BIOLOGY AND MEDICINE CARCINOGENESIS Carcinogens Cell growth Chromosome Aberrations CHROMOSOMES Circadian rhythm Cycadopsida Cycasin EXPANSION GAMMA RADIATION GERMINATION Glycosides GROWTH Irradiation Light MALFORMATIONS Metabolism, Tissue Distribution, and Toxicology METHANOL METHYL RADICALS ORGANIC NITROGEN COMPOUNDS Oxidases OXYGEN COMPOUNDS Pharmacology Pigments Pineal gland PLANT CELLS Plant Poisoning PLANTS QUANTITY RATIO RADIATION DOSES Radiation Effects RADIATION INJURIES RADIOMIMETIC DRUGS Root tips ROOTS Seeds SUGARS Toxicology Ultraviolet radiation
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Beschreibung
Zusammenfassung:	Cycasin, methylazoxy-methanol-β-glucoside, a carcinogenic compound that occurs naturally in cycad plants, induces chromosome aberrations in the root-tip cells of Allium cepa. Germination and growth in an aqueous solution of cycasin at a concentration of only 3 percent of that found in Cycas circinalis induced as many aberrations in chromosomes as did about 200 roentgens of gamma irradiation.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.149.3683.541