Cleft Palate in the Mouse: A Teratogenic Index of Glucocorticoid Potency

Cleft Palate in the Mouse: A Teratogenic Index of Glucocorticoid Potency

Clinically equivalent doses of hydrocortisone, prednisolone, and dexamethasone have progressively increasing teratogenic activity as judged by their ability to induce cleft palate in the offspring of pregnant mice treated with these drugs during the middle period of gestation. Mole for mole, dexamet...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1965-01, Vol.147 (3656), p.402-403
Hauptverfasser: Pinsky, Leonard, DiGeorge, Angelo M.
Format: Artikel
Sprache:eng
Schlagworte:
Absorption spectra
Animals
Cleft Palate
Desoxycorticosterone
Dexamethasone
Dosage
Female
Fetus
Glucocorticoids
Humans
Hydrocortisone - toxicity
Male animals
Maternal-Fetal Exchange
Mice
Prednisolone
Pregnancy
Pregnancy, Animal
Property titles
Steroids
Teratogens
Toxicology
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Beschreibung
Zusammenfassung:Clinically equivalent doses of hydrocortisone, prednisolone, and dexamethasone have progressively increasing teratogenic activity as judged by their ability to induce cleft palate in the offspring of pregnant mice treated with these drugs during the middle period of gestation. Mole for mole, dexamethasone is at least 300 times more teratogenic than hydrocortisone. The enhanced teratogenicity of dexamethasone probably does not result from its relatively decreased mineralocorticoid activity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.147.3656.402