Radiation-Chemical Oxidation of Peptides in the Solid State

Gamma-ray irradiation of polypeptides as highly dispersed fluffs under oxygen leads to chemical degradation of the peptide bond with the remarkably high oxygen consumption of about one molecule per 2 ev of absorbed energy. A radical chain mechanism appears to be involved, and there is evidence that...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1964-10, Vol.146 (3641), p.250-252
Hauptverfasser:	Garrison, Warren M., Jayko, Michael E., Bennett-Corniea, Winifred
Format:	Artikel
Sprache:	eng
Schlagworte:	ALANINE Ammonia Chemical Phenomena CHEMICAL REACTIONS CHEMISTRY Chromosomes COLLOIDS DECOMPOSITION ENERGY LEVELS EV RANGE GAMMA RADIATION Gelatin GELATINE Gelatins Histology Leukemia Lymphoma OXIDATION Oxidation-Reduction Oxygen PEPTIDES RADIATION CHEMISTRY RADIATION EFFECTS REACTION KINETICS SOLIDS Tumors Viruses
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Beschreibung
Zusammenfassung:	Gamma-ray irradiation of polypeptides as highly dispersed fluffs under oxygen leads to chemical degradation of the peptide bond with the remarkably high oxygen consumption of about one molecule per 2 ev of absorbed energy. A radical chain mechanism appears to be involved, and there is evidence that excited states of the polypeptide aggregate undergo chemical quenching by molecular oxygen.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.146.3641.250