Induced Phenotypic Resistance to an Antimetabolite

Induced Phenotypic Resistance to an Antimetabolite

Resistance to bacteriostasis by 2-thiazole alanine develops rapidly; however, such resistance is lost during growth in the absence of the analog. This induced resistance is accompanied by increased formation of an enzyme sensitive to 2-thiazole alanine. Maintenance of the elevated enzyme levels in g...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1960-05, Vol.131 (3411), p.1449-1449
1. Verfasser: Moyed, H. S.
Format: Artikel
Sprache:eng
Schlagworte:
Alanine
Antimetabolites
Antimetabolites - pharmacology
Cell growth
Enzymes
Escherichia coli - pharmacology
Inductive reasoning
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Zusammenfassung:Resistance to bacteriostasis by 2-thiazole alanine develops rapidly; however, such resistance is lost during growth in the absence of the analog. This induced resistance is accompanied by increased formation of an enzyme sensitive to 2-thiazole alanine. Maintenance of the elevated enzyme levels in growing cells, like resistance, requires the presence of the analog.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.131.3411.1449