Sulfoxide Reduction in Relation to Organophosphorus Insecticide Detoxification

Sulfoxide Reduction in Relation to Organophosphorus Insecticide Detoxification

Carbophenothion sulfoxide, an oxidative metabolite of carbophenothion, is reduced to carbophenothion in the living rat and by an in vitro system containing rat liver enzyme, reduced nicotinamide adenine dinucleotide phosphate, and flavin adenine dinucleotide phosphate. Reduction of sulfoxides, forme...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1976-01, Vol.191 (4223), p.187-188
Hauptverfasser: DeBaun, Jack R., Menn, Julius J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cholinesterase Inhibitors - metabolism
Chromosomes
Enzymes
Insecticides
Insecticides - metabolism
Liver
Liver - enzymology
Liver - metabolism
Microtubules
Neurons
Organophosphorus Compounds
Oxidation
Rats
Sulfides
Sulfoxides
Sulfoxides - metabolism
Thiones - metabolism
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Beschreibung
Zusammenfassung:Carbophenothion sulfoxide, an oxidative metabolite of carbophenothion, is reduced to carbophenothion in the living rat and by an in vitro system containing rat liver enzyme, reduced nicotinamide adenine dinucleotide phosphate, and flavin adenine dinucleotide phosphate. Reduction of sulfoxides, formed metabolically from certain commercial organophosphorus insecticides, may be important in ameliorating the toxicity of these compounds.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1246606