β-Adrenergic Receptor Involvement in 6-Hydroxydopamine-Induced Supersensitivity in Rat Cerebral Cortex

The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of β-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results sugges...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1976-11, Vol.194 (4265), p.624-626
Hauptverfasser:	Sporn, Jonathan R., Harden, T. Kendall, Wolfe, Barry B., Molinoff, Perry B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - metabolism Animals Binding Sites Cerebral cortex Cerebral Cortex - drug effects Cerebrum Cyclic AMP - metabolism Denervation Density Dose-Response Relationship, Drug Fossils Homogenization Horses Hydroxydopamines - pharmacology Isoproterenol - pharmacology Male Nerves Norepinephrine Rats Receptors Receptors, Adrenergic - drug effects Receptors, Adrenergic, beta - drug effects Receptors, Adrenergic, beta - metabolism
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Zusammenfassung:	The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of β-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results suggest that changes in the density of adrenergic receptors are involved in 6-hydroxydopamine-induced supersensitivity at central noradrenergic synapses.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.10626