Therapy/imaging array-based system and technology for intense ultrasound surgery

Minimally invasive, miniature (2.2- × 50-mm aperture, 3.3-mm diameter) dual-mode linear arrays have been developed into low-cost disposable probes with high acoustic power output (120 W/cm2 at the source), high transmit efficiency (>65% typical), and good imaging performance (50% fractional bandwidth, >100-mm-deep field of view). These therapy/imaging probes have been integrated into a flexible intense ultrasound surgery platform which also includes conventional diagnostic imaging probes. A system architecture has been developed which includes a 64-channel therapy driver with software selection of array aperture and phasing (λ/16), frequency (0.5–8 MHz), drive amplitude (5 W/channel, nominal), rotational steering (±180 deg), and temporal sequencing/switching of imaging/therapy/monitoring modes. System software includes graphical and text-based script mode control of therapeutic treatment. Real-time monitoring of electric power per channel, temperature sensors, and thermal effects provide a range of feedback and safety. Numerous system and probe technological issues such as electrical interconnect and matching, acoustic coupling, thermal control, and maintaining probe efficiency have been addressed. The array-based imaging/therapy system has produced encouraging results in preclinical studies of bulk tissue ablation and imaging.