Metabolic shock wave after acoustically-mediated blood-brain barrier opening: Investigations of CSF and serum metabolomes

In this study, rats' right striata were exposed to microbubble-assisted ultrasound in order to open the BBB. This work aimed to investigate the metabolic consequences of this process on rat's serum and cerebrospinal fluid using the 1H-NMR spectroscopy study. The biochemical analysis of CSF and serum metabolomes indicated significant changes in several metabolic pathways related to alternative sources of cellular energetic metabolism, immediately and up to 48 h after the BBB opening. These findings could highlight the implication of hypoxia-associated processes into the BBB opening or the modulation of neurotransmission.