Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid
Recently, “low dose and long term” erythromycin (EM) treatment has been reported as effective on chronic lower respiratory tract disease, including diffuse panbronchiolitis (DPB). However the effective mechanism of EM is still obscure. In this study, we investigated the effect of EM on intrapulmonar...
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| Veröffentlicht in: | Kansenshogaku Zasshi 1992/02/20, Vol.66(2), pp.194-200 |
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| creator | SAKITO, Osamu KADOTA, Jun-ichi ODA, Hiroshige MUKAE, Hiroshi YOKOYAMA, Atsushi KAWAMOTO, Sadahiro KASEDA, Makoto MORIKAWA, Toru KUSANO, Shiro ASAI, Tsunehiko SAWA, Hideaki MORIKAWA, Nobuo SHUKUWA, Chieko SENJU, Reiko FUKUSHIMA, Kiyoyasu KOMORI, Kiyokazu KOHNO, Shigeru HARA, Kohei HIRATANI, Kazuhito HIROTA, Masaki |
| description | Recently, “low dose and long term” erythromycin (EM) treatment has been reported as effective on chronic lower respiratory tract disease, including diffuse panbronchiolitis (DPB). However the effective mechanism of EM is still obscure. In this study, we investigated the effect of EM on intrapulmonary influx of neutrophils by intratracheal injection of lipopolysaccharide (LPS), and thef ollowing results were obtained. 1) The intrapulmonary influx of neutrophils was significantly suppressed (p |
| doi_str_mv | 10.11150/kansenshogakuzasshi1970.66.194 |
| format | Article |
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However the effective mechanism of EM is still obscure. In this study, we investigated the effect of EM on intrapulmonary influx of neutrophils by intratracheal injection of lipopolysaccharide (LPS), and thef ollowing results were obtained. 1) The intrapulmonary influx of neutrophils was significantly suppressed (p<0.001) in mice intraperitoneally injected with EM at 5 mg per animal 2 hr before intratracheal injection of LPS (control group: 6.5 ± 0.8×105 vs EM-treated group: 1.7 ± 0.3×105), but not 10 hr before lung challenge. This inhibition was observed at 6 hr after lung challenge, and became maximum with 84% suppression at 24hr. 2) The intrapulmonary influx of neutrophils was not affected when EM was injected intraperitoneally daily for 3, 7, or 14 days, and lung challenge was performed 24 hr after the final administration of EM. 3) The number of neutrophils in the peripheral blood was not affected by EM. These results suggest that EM treatment impairs the capacity for pulmonary inflammation by reducing, at least in part, the migration of neutrophils to inflammatory sites.</description><identifier>ISSN: 0387-5911</identifier><identifier>EISSN: 1884-569X</identifier><identifier>DOI: 10.11150/kansenshogakuzasshi1970.66.194</identifier><language>eng ; jpn</language><publisher>The Japanese Association for Infectious Diseases</publisher><subject>erythromycin ; intrapulmonary influx ; lipopolysaccharid ; neutrophil</subject><ispartof>Kansenshogaku Zasshi, 1992/02/20, Vol.66(2), pp.194-200</ispartof><rights>The Japansese Association for Infectious Diseases</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids></links><search><creatorcontrib>SAKITO, Osamu</creatorcontrib><creatorcontrib>KADOTA, Jun-ichi</creatorcontrib><creatorcontrib>ODA, Hiroshige</creatorcontrib><creatorcontrib>MUKAE, Hiroshi</creatorcontrib><creatorcontrib>YOKOYAMA, Atsushi</creatorcontrib><creatorcontrib>KAWAMOTO, Sadahiro</creatorcontrib><creatorcontrib>KASEDA, Makoto</creatorcontrib><creatorcontrib>MORIKAWA, Toru</creatorcontrib><creatorcontrib>KUSANO, Shiro</creatorcontrib><creatorcontrib>ASAI, Tsunehiko</creatorcontrib><creatorcontrib>SAWA, Hideaki</creatorcontrib><creatorcontrib>MORIKAWA, Nobuo</creatorcontrib><creatorcontrib>SHUKUWA, Chieko</creatorcontrib><creatorcontrib>SENJU, Reiko</creatorcontrib><creatorcontrib>FUKUSHIMA, Kiyoyasu</creatorcontrib><creatorcontrib>KOMORI, Kiyokazu</creatorcontrib><creatorcontrib>KOHNO, Shigeru</creatorcontrib><creatorcontrib>HARA, Kohei</creatorcontrib><creatorcontrib>HIRATANI, Kazuhito</creatorcontrib><creatorcontrib>HIROTA, Masaki</creatorcontrib><title>Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid</title><title>Kansenshogaku Zasshi</title><addtitle>J. J. A. Inf. D</addtitle><description>Recently, “low dose and long term” erythromycin (EM) treatment has been reported as effective on chronic lower respiratory tract disease, including diffuse panbronchiolitis (DPB). However the effective mechanism of EM is still obscure. In this study, we investigated the effect of EM on intrapulmonary influx of neutrophils by intratracheal injection of lipopolysaccharide (LPS), and thef ollowing results were obtained. 1) The intrapulmonary influx of neutrophils was significantly suppressed (p<0.001) in mice intraperitoneally injected with EM at 5 mg per animal 2 hr before intratracheal injection of LPS (control group: 6.5 ± 0.8×105 vs EM-treated group: 1.7 ± 0.3×105), but not 10 hr before lung challenge. This inhibition was observed at 6 hr after lung challenge, and became maximum with 84% suppression at 24hr. 2) The intrapulmonary influx of neutrophils was not affected when EM was injected intraperitoneally daily for 3, 7, or 14 days, and lung challenge was performed 24 hr after the final administration of EM. 3) The number of neutrophils in the peripheral blood was not affected by EM. These results suggest that EM treatment impairs the capacity for pulmonary inflammation by reducing, at least in part, the migration of neutrophils to inflammatory sites.</description><subject>erythromycin</subject><subject>intrapulmonary influx</subject><subject>lipopolysaccharid</subject><subject>neutrophil</subject><issn>0387-5911</issn><issn>1884-569X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><recordid>eNp9kF9LwzAUxYMoOHTfoW8-dSZtmjZPImPqYOiDCr6Vmz9ds3VNSVqwfnozK3tTuNzLhXN-cA5CNwQvCCEZvt1D63Xra7uF_fAF3teG8BwvGFsQTs_QjBQFjTPGP87RDKdFHmeckEs0994IjDGnOMmSGWpXVaVlH9kqWrmxr509jNK0kW2jdds76IbmYFtwY3irZvg8Cp_10Dvb1abxkRgnXRhZa2jCtws8E_xBuTGd7WwzepCyBmfUNbqooPF6_nuv0PvD6m35FG9eHtfL-00sScFpLHLFlAJR4UIWQiWaK6JzKUCRFGPQFCiVOucMsoSrNEklZYIIjjXkqmB5eoXuJq501nunq7Jz5hBilASXPw2WfzRYMlaGBgPhdSLsfA9bffKD641s9H_2ZFqBclIf05e6Tb8BTXyPDQ</recordid><startdate>19920220</startdate><enddate>19920220</enddate><creator>SAKITO, Osamu</creator><creator>KADOTA, Jun-ichi</creator><creator>ODA, Hiroshige</creator><creator>MUKAE, Hiroshi</creator><creator>YOKOYAMA, Atsushi</creator><creator>KAWAMOTO, Sadahiro</creator><creator>KASEDA, Makoto</creator><creator>MORIKAWA, Toru</creator><creator>KUSANO, Shiro</creator><creator>ASAI, Tsunehiko</creator><creator>SAWA, Hideaki</creator><creator>MORIKAWA, Nobuo</creator><creator>SHUKUWA, Chieko</creator><creator>SENJU, Reiko</creator><creator>FUKUSHIMA, Kiyoyasu</creator><creator>KOMORI, Kiyokazu</creator><creator>KOHNO, Shigeru</creator><creator>HARA, Kohei</creator><creator>HIRATANI, Kazuhito</creator><creator>HIROTA, Masaki</creator><general>The Japanese Association for Infectious Diseases</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>19920220</creationdate><title>Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid</title><author>SAKITO, Osamu ; KADOTA, Jun-ichi ; ODA, Hiroshige ; MUKAE, Hiroshi ; YOKOYAMA, Atsushi ; KAWAMOTO, Sadahiro ; KASEDA, Makoto ; MORIKAWA, Toru ; KUSANO, Shiro ; ASAI, Tsunehiko ; SAWA, Hideaki ; MORIKAWA, Nobuo ; SHUKUWA, Chieko ; SENJU, Reiko ; FUKUSHIMA, Kiyoyasu ; KOMORI, Kiyokazu ; KOHNO, Shigeru ; HARA, Kohei ; HIRATANI, Kazuhito ; HIROTA, Masaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1894-b7d6ddabf08c8bd2e9d1e7cbad1300ae4a44ce796a529d323c46b1b90ea7d8673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; jpn</language><creationdate>1992</creationdate><topic>erythromycin</topic><topic>intrapulmonary influx</topic><topic>lipopolysaccharid</topic><topic>neutrophil</topic><toplevel>online_resources</toplevel><creatorcontrib>SAKITO, Osamu</creatorcontrib><creatorcontrib>KADOTA, Jun-ichi</creatorcontrib><creatorcontrib>ODA, Hiroshige</creatorcontrib><creatorcontrib>MUKAE, Hiroshi</creatorcontrib><creatorcontrib>YOKOYAMA, Atsushi</creatorcontrib><creatorcontrib>KAWAMOTO, Sadahiro</creatorcontrib><creatorcontrib>KASEDA, Makoto</creatorcontrib><creatorcontrib>MORIKAWA, Toru</creatorcontrib><creatorcontrib>KUSANO, Shiro</creatorcontrib><creatorcontrib>ASAI, Tsunehiko</creatorcontrib><creatorcontrib>SAWA, Hideaki</creatorcontrib><creatorcontrib>MORIKAWA, Nobuo</creatorcontrib><creatorcontrib>SHUKUWA, Chieko</creatorcontrib><creatorcontrib>SENJU, Reiko</creatorcontrib><creatorcontrib>FUKUSHIMA, Kiyoyasu</creatorcontrib><creatorcontrib>KOMORI, Kiyokazu</creatorcontrib><creatorcontrib>KOHNO, Shigeru</creatorcontrib><creatorcontrib>HARA, Kohei</creatorcontrib><creatorcontrib>HIRATANI, Kazuhito</creatorcontrib><creatorcontrib>HIROTA, Masaki</creatorcontrib><collection>CrossRef</collection><jtitle>Kansenshogaku Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAKITO, Osamu</au><au>KADOTA, Jun-ichi</au><au>ODA, Hiroshige</au><au>MUKAE, Hiroshi</au><au>YOKOYAMA, Atsushi</au><au>KAWAMOTO, Sadahiro</au><au>KASEDA, Makoto</au><au>MORIKAWA, Toru</au><au>KUSANO, Shiro</au><au>ASAI, Tsunehiko</au><au>SAWA, Hideaki</au><au>MORIKAWA, Nobuo</au><au>SHUKUWA, Chieko</au><au>SENJU, Reiko</au><au>FUKUSHIMA, Kiyoyasu</au><au>KOMORI, Kiyokazu</au><au>KOHNO, Shigeru</au><au>HARA, Kohei</au><au>HIRATANI, Kazuhito</au><au>HIROTA, Masaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid</atitle><jtitle>Kansenshogaku Zasshi</jtitle><addtitle>J. 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This inhibition was observed at 6 hr after lung challenge, and became maximum with 84% suppression at 24hr. 2) The intrapulmonary influx of neutrophils was not affected when EM was injected intraperitoneally daily for 3, 7, or 14 days, and lung challenge was performed 24 hr after the final administration of EM. 3) The number of neutrophils in the peripheral blood was not affected by EM. These results suggest that EM treatment impairs the capacity for pulmonary inflammation by reducing, at least in part, the migration of neutrophils to inflammatory sites.</abstract><pub>The Japanese Association for Infectious Diseases</pub><doi>10.11150/kansenshogakuzasshi1970.66.194</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0387-5911 |
| ispartof | Kansenshogaku Zasshi, 1992/02/20, Vol.66(2), pp.194-200 |
| issn | 0387-5911 1884-569X |
| language | eng ; jpn |
| recordid | cdi_crossref_primary_10_11150_kansenshogakuzasshi1970_66_194 |
| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Alma/SFX Local Collection |
| subjects | erythromycin intrapulmonary influx lipopolysaccharid neutrophil |
| title | Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid |
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