Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid

Effect of Erythromycin on Intrapulmonary Influx of Neutrophils by Intratracheal Injection of Lipopolysaccharid

Recently, “low dose and long term” erythromycin (EM) treatment has been reported as effective on chronic lower respiratory tract disease, including diffuse panbronchiolitis (DPB). However the effective mechanism of EM is still obscure. In this study, we investigated the effect of EM on intrapulmonar...

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Veröffentlicht in:Kansenshogaku Zasshi 1992/02/20, Vol.66(2), pp.194-200
Hauptverfasser: SAKITO, Osamu, KADOTA, Jun-ichi, ODA, Hiroshige, MUKAE, Hiroshi, YOKOYAMA, Atsushi, KAWAMOTO, Sadahiro, KASEDA, Makoto, MORIKAWA, Toru, KUSANO, Shiro, ASAI, Tsunehiko, SAWA, Hideaki, MORIKAWA, Nobuo, SHUKUWA, Chieko, SENJU, Reiko, FUKUSHIMA, Kiyoyasu, KOMORI, Kiyokazu, KOHNO, Shigeru, HARA, Kohei, HIRATANI, Kazuhito, HIROTA, Masaki
Format: Artikel
Sprache:eng ; jpn
Schlagworte:
erythromycin
intrapulmonary influx
lipopolysaccharid
neutrophil
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Zusammenfassung:Recently, “low dose and long term” erythromycin (EM) treatment has been reported as effective on chronic lower respiratory tract disease, including diffuse panbronchiolitis (DPB). However the effective mechanism of EM is still obscure. In this study, we investigated the effect of EM on intrapulmonary influx of neutrophils by intratracheal injection of lipopolysaccharide (LPS), and thef ollowing results were obtained. 1) The intrapulmonary influx of neutrophils was significantly suppressed (p
ISSN:0387-5911
1884-569X
DOI:10.11150/kansenshogakuzasshi1970.66.194