Laboratory and Clinical Studies on Talampicillin in Urological Field

1. Antibacterial Activity Antibacterial activities of talampicillin against clinical isolates of E. coli and Serratia were similar to or less than those of ampicillin. 2. Blood level A single oral dose of 250mg of talampicillin in fasting state produced a peak level of 4.3μg/ml at 1-hr after administration and showed a level of 0.2μg/ml even at 6-hr. 3. Urinary excretion A single oral dose of 250mg of talampicillin produced an average urinary excretion rate of 42.5% in the first 6-hr period after administration. 4. Clinical efficiency Use of talampicillin for 26 patients with infections in urinary tract or genital organs gave the results of 15 excellent cases, 6 good and 5 poor. The effective rate was 80.8%. 5. Side effect In 2 of 26 cases nausea was noted and in one case of them the medication was discontinued because of it.