Maturation of rat cerebellar Purkinje cells reveals an atypical Ca 2+ channel current that is inhibited by ω‐agatoxin IVA and the dihydropyridine (−)‐( S )‐Bay K8644
To determine if the properties of Ca 2+ channels in cerebellar Purkinje cells change during postnatal development, we recorded Ca 2+ channel currents from Purkinje cells in cerebellar slices of mature (postnatal days (P) 40–50) and immature (P13–20) rats. We found that at P40–50, the somatic Ca 2+ c...
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| Veröffentlicht in: | The Journal of physiology 2007-02, Vol.578 (3), p.693-714 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | To determine if the properties of Ca
2+
channels in cerebellar Purkinje cells change during postnatal development, we recorded Ca
2+
channel currents from Purkinje cells in cerebellar slices of mature (postnatal days (P) 40–50) and immature (P13–20) rats. We found that at P40–50, the somatic Ca
2+
channel current was inhibited by ω‐agatoxin IVA at concentrations selective for P‐type Ca
2+
channels (∼85%; IC
50
, |
|---|---|
| ISSN: | 0022-3751 1469-7793 |
| DOI: | 10.1113/jphysiol.2006.121905 |