Forskolin but not isoprenaline increases sodium current from frog cardiac myocytes

The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch-clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between -50 and +30 mV. The forskolin-induc...

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Veröffentlicht in:	Experimental physiology 1990-11, Vol.75 (6), p.843-846
Hauptverfasser:	Bonvallet, R, Lemtiri-Chlieh, F, Rougier, O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colforsin - analogs & derivatives Colforsin - pharmacology Heart - drug effects Heart - physiology In Vitro Techniques Isoproterenol - pharmacology Membrane Potentials - drug effects Rana esculenta Sodium Channels - drug effects Tetrodotoxin - pharmacology
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Zusammenfassung:	The effect of forskolin on sodium current (INa) was studied in enzymatically dispersed frog atrial myocytes. The single pipette patch-clamp technique was used, with a low external sodium concentration. Forskolin (0.5 microM) increased INa at all potentials between -50 and +30 mV. The forskolin-induced increase of INa was mimicked by 1,9-dideoxyforskolin (0.5 microM) but not by isoprenaline (2 microM). These results suggest that forskolin can modulate INa through a mechanism that does not involve the production of cyclic AMP.
ISSN:	0958-0670 1469-445X
DOI:	10.1113/expphysiol.1990.sp003466