Prospective, controlled, blinded, randomized crossover trial evaluating the effect of maropitant versus ondansetron on inhibiting tranexamic acid‐evoked emesis

Objective To evaluate the incidence of tranexamic acid (TXA)‐induced nausea and vomiting after the prophylactic use of 2 antiemetics, ondansetron and maropitant, compared with saline. Design Prospective, blinded, placebo‐controlled, randomized, crossover study. Setting University research facility. Animals Eight adult, purpose‐bred Beagles. Intervention Dogs received 3 treatments on 3 occasions with a 3‐week washout period. Either maropitant (1 mg/kg), ondansetron (0.2 mg/kg), or saline solution was given intravenously in equal volumes, followed 10 minutes later by 50 mg/kg IV TXA. A blinded observer evaluated the dogs for signs of vomiting and nausea for 30 minutes. The severity of nausea was assessed with a visual analog scale (VAS) and recorded at baseline before TXA, and at the end of 3 observational periods: 0–5, 5–15, and 15–30 minutes after TXA. A generalized linear mixed effect model was used to assess for group and period effects. Statistical significance was set at P