Pilot clinical study of carmustine associated with a lipid nanoemulsion in combination with vincristine and prednisone for the treatment of canine lymphoma

A lipid nanoemulsion (LDE) resembling low‐density lipoprotein can target malignant tumours. In in vivo and clinical studies, association of chemotherapeutic agents to LDE decreased their toxicity and increased pharmacological action. Here, safety of LDE as carmustine carrier (50 mg m⁻², intravenous)...

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Veröffentlicht in:	Veterinary & comparative oncology 2015-09, Vol.13 (3), p.184-193
Hauptverfasser:	Lucas, S. R. R., Maranhão, R. C., Guerra, J. L., Coelho, B. M. P., Barboza, R., Pozzi, D. H. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Alkylating - administration & dosage Antineoplastic Agents, Alkylating - adverse effects Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - adverse effects Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - adverse effects Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brazil cancer chemotherapy canine lymphoma treatment Carmustine - administration & dosage Carmustine - adverse effects Disease-Free Survival Dog Diseases - diagnosis Dog Diseases - drug therapy Dogs Fat Emulsions, Intravenous - administration & dosage Female Kaplan-Meier Estimate Lymphoma, B-Cell - diagnosis Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - veterinary Lymphoma, T-Cell - diagnosis Lymphoma, T-Cell - drug therapy Lymphoma, T-Cell - veterinary Male nanoemulsions nanoparticles Pilot Projects Prednisone - administration & dosage Prednisone - adverse effects solid lipid particles Vincristine - administration & dosage Vincristine - adverse effects
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