The evolving role of lyophilized plasma in remote damage control resuscitation in the F rench A rmed F orces H ealth S ervice

Freeze‐dried plasma was developed by the US A rmy for the resuscitation of combat casualties during W orld W ar II. The French Military Blood Institute began producing French lyophilized plasma ( FLYP ) in 1949, in accordance with F rench blood product guidelines. Since 2010, a photochemical pathogen inactivation process has been implemented to reduce the remaining transfusion‐related infectious risk. All quality controls for this procedure verify that the hemostatic properties of FLYP are conserved. FLYP is compatible with all blood types, can be stored at room temperature for 2 years, and its reconstitution requires less than 6 minutes. As a result, FLYP allows quick delivery of all the coagulation proteins and the application of a 1:1 ratio of FLYP and red blood cells in the context of a massive transfusion. Hemovigilance data collected in F rance since 1994 have included FLYP . Results indicate no reporting of infection related to the use of FLYP . Clinical monitoring with a focus on hemostasis was implemented in 2002 and expanded in 2010. The data, obtained from overseas operations, confirmed the indications, the safety and the clinical efficacy of FLYP . Further research is needed to determine specific indications for FLYP in the therapeutic management of civilian patients with severe hemorrhage.