Distribution of the HLA‐DPB1 alleles in a Russian population living in the Chelyabinsk region (South Ural of Russia)

The purpose of this work was to establish the distribution of HLA‐DPB1 alleles in Russians living in the Chelyabinsk region (Russia). DPB1 frequencies were determined in 100 unrelated Russian, living in the Chelyabinsk region. All subjects were healthy unrelated blood donors, between 18 and 55 years...

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Veröffentlicht in:	HLA 2019-12, Vol.94 (S2), p.34-39
Hauptverfasser:	Burmistrova, Alexandra L., Vavilov, Mikhail N., Khromova, Elena B., Suslova, Tatiana A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Blood Donors - statistics & numerical data Female gene frequencies Gene Frequency Genetics, Population HLA-DP beta-Chains - genetics HLA‐DPB1 Humans Male Middle Aged NGS Polymorphism, Genetic population Russia - epidemiology Young Adult
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Zusammenfassung:	The purpose of this work was to establish the distribution of HLA‐DPB1 alleles in Russians living in the Chelyabinsk region (Russia). DPB1 frequencies were determined in 100 unrelated Russian, living in the Chelyabinsk region. All subjects were healthy unrelated blood donors, between 18 and 55 years of age. Typing was performed by NGS (DNA‐technology, Moscow). For population genetics analysis GENE[RATE] (https://hla-net.eu/tools/) software was used. DPB104:01 prevails in this population (gf = 0.3667). Other frequent HLA‐DPB1 alleles were: DPB104:02, DPB102:01, DPB103:01 (gf = 0.1490; 0.1481; 0.1385, respectively). Rare alleles (gf ≤ 0.03) were DPB117:01, DPB101:01, DPB106:01, DPB114:01, DPB105:01, DPB113:01, DPB109:01, DPB110:01, DPB111:01, DPB123:01, DPB1124:01, DPB115:01, DPB116:01, DPB1105:01, DPB1*150:01.
ISSN:	2059-2302 2059-2310
DOI:	10.1111/tan.13765