Neuropathologic assessment of participants in two multi‐center longitudinal observational studies: The A lzheimer D isease N euroimaging I nitiative ( ADNI ) and the D ominantly I nherited A lzheimer N etwork ( DIAN )
It has been hypothesized that the relatively rare autosomal dominant A lzheimer disease ( ADAD ) may be a useful model of the more frequent, sporadic, late‐onset AD ( LOAD ). Individuals with ADAD have a predictable age at onset and the biomarker profile of ADAD participants in the preclinical stage...
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Veröffentlicht in: | Neuropathology 2015-08, Vol.35 (4), p.390-400 |
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Sprache: | eng |
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Zusammenfassung: | It has been hypothesized that the relatively rare autosomal dominant
A
lzheimer disease (
ADAD
) may be a useful model of the more frequent, sporadic, late‐onset
AD
(
LOAD
). Individuals with
ADAD
have a predictable age at onset and the biomarker profile of
ADAD
participants in the preclinical stage may be used to predict disease progression and clinical onset. However, the extent to which the pathogenesis and neuropathology of
ADAD
overlaps with that of
LOAD
is equivocal. To address this uncertainty, two multicenter longitudinal observational studies, the
A
lzheimer
D
isease
N
euroimaging
I
nitiative (
ADNI
) and the
D
ominantly
I
nherited
A
lzheimer
N
etwork (
DIAN
), leveraged the expertise and resources of the existing
K
night
A
lzheimer
D
isease
R
esearch
C
enter (
ADRC
) at
W
ashington
U
niversity
S
chool of
M
edicine,
S
t.
L
ouis,
M
issouri,
USA
, to establish a
N
europathology
C
ore (
NPC
). The
ADNI/DIAN‐NPC
is systematically examining the brains of all participants who come to autopsy at the 59
ADNI
sites in the
USA
and
C
anada and the 14
DIAN
sites in the
USA
(eight),
A
ustralia (three),
UK
(one) and
G
ermany (two). By 2014, 41
ADNI
and 24
DIAN
autopsies (involving nine participants and 15 family members) had been performed. The autopsy rate in the
ADNI
cohort in the most recent year was 93% (total since
NPC
inception: 70%). In summary, the
ADNI/DIAN NPC
has implemented a standard protocol for all sites to solicit permission for brain autopsy and to send brain tissue to the
NPC
for a standardized, uniform and state‐of‐the‐art neuropathologic assessment. The benefit to
ADNI
and
DIAN
of the implementation of the
NPC
is very clear. The
NPC
provides final “gold standard” neuropathological diagnoses and data against which the antecedent observations and measurements of
ADNI
and
DIAN
can be compared. |
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ISSN: | 0919-6544 1440-1789 |
DOI: | 10.1111/neup.12205 |