The value of serum aspartate aminotransferase and gamma-glutamyl transpetidase as biomarkers in hepatotoxicity

Background & Aims The current definition of the pattern of liver injury in hepatotoxicity (DILI) is given by the R (ratio) value, dividing alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in upper limits of normal at DILI onset. We aimed to explore the validity of using aspartate am...

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Veröffentlicht in:Liver international 2015-11, Vol.35 (11), p.2474-2482
Hauptverfasser: Robles-Diaz, Mercedes, Garcia-Cortes, Miren, Medina-Caliz, Inmaculada, Gonzalez-Jimenez, Andres, Gonzalez-Grande, Rocio, Navarro, Jose M., Castiella, Agustin, Zapata, Eva M., Romero-Gomez, Manuel, Blanco, Sonia, Soriano, German, Hidalgo, Ramon, Ortega-Torres, Maria, Clavijo, Encarnacion, Bermudez-Ruiz, Pilar M., Lucena, M. Isabel, Andrade, Raúl J.
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Sprache:eng
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Zusammenfassung:Background & Aims The current definition of the pattern of liver injury in hepatotoxicity (DILI) is given by the R (ratio) value, dividing alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in upper limits of normal at DILI onset. We aimed to explore the validity of using aspartate aminotransferase (AST) and gamma‐glutamyl transpeptidase (GGT) as biomarkers of hepatocelullar and cholestatic damage, respectively, when calculating the R value. Methods Clinical, laboratory and histological data from 588 DILI episodes included in the Spanish DILI Registry were analyzed. Linear regression analysis was performed to establish the most appropriate cut‐off points for hepatocellular and cholestatic patterns when calculating R with AST and GGT. Results The overall agreement between ALT/ALP and AST/ALP was 76%, with 96%, 61% and 41% agreement in the hepatocellular (R ≥ 5), cholestatic (R ≤ 2) and mixed groups respectively (P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.12834