Application of D‐optimal design for automatic solvent extraction of carotenoid from orange peel

Automatic solvent extraction (ASE) was employed to acquire orange peel extract rich in carotenoid by means of several solvents (hexane, heptane, and chloroform). D‐optimal design was used for the design of experiments, modeling the experimental data, and optimization of the extraction process. Selected process parameters (extraction time, particle size of the peel, and solvent type) for the current ASE system were found statistically significant at p