The protective effects of pomegranate juice on lead acetate‐induced neurotoxicity in the male rat: A histomorphometric and biochemical study

The protective effects of pomegranate juice on lead acetate‐induced neurotoxicity in the male rat: A histomorphometric and biochemical study

The purpose of this study was to investigate the potential side‐effects of lead acetate (LA), which is toxic to the nerves, blood and muscles, in the rat brain. The neuroprotective effects of pomegranate juice (PJ) against LA exposure were also observed. The experiment involved 28 male Wistar albino...

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Veröffentlicht in:Journal of food biochemistry 2022-04, Vol.46 (4), p.e13881-n/a
Hauptverfasser: Annaç, Ebru, Uçkun, Miraç, Özkaya, Ahmet, Yoloğlu, Ertan, Pekmez, Hıdır, Bulmuş, Özgür, Aydın, Ali
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholinesterase
Animals
Antioxidants - pharmacology
Female
Fruit and Vegetable Juices
Glutathione
Lead - toxicity
Male
Neurotoxicity Syndromes
Organometallic Compounds - toxicity
Pomegranate
Rats
Rats, Wistar
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Zusammenfassung:The purpose of this study was to investigate the potential side‐effects of lead acetate (LA), which is toxic to the nerves, blood and muscles, in the rat brain. The neuroprotective effects of pomegranate juice (PJ) against LA exposure were also observed. The experiment involved 28 male Wistar albino rats aged 12 weeks. These were divided into four groups: Control, PJ, LA and LA+PJ. Stereological techniques were employed to determine hippocampal volume in each rat brain. Biochemical investigations and histopathological examinations were also performed. Analysis demonstrated a significant decrease in hippocampal volume in the LA group compared to the control group (p 
ISSN:0145-8884
1745-4514
DOI:10.1111/jfbc.13881